Inflammation. Disc Degeneration. There is a connection.
Inflammation acts as the body’s response system to damaging
stimuli (injury, pathogens, metabolic stress – a disc herniation compressing a nerve!) as it attempts to repair itself
before the harm was done. Rethwill Chiropractic Clinic is never
shocked at how the body takes care of itself!
Rethwill Chiropractic Clinic sees its Eugene chiropractic care as a partner of
the body’s system in healing especially
when spine pain is an issue. Chiropractic care uses
many tools like spinal manipulation, exercise, and nutrition to take care of
the body. Melatonin is one nutritional tool that is showing value
in its ability to interrupt the inflammatory process
related disc herniation that brings about pain relief: back, neck, spine-related.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6
(IL-6) and tumor necrosis factor-α (TNF-α) are related
to intervertebral disc degeneration. (1) IL-1 β in fact promotes
itself, its own expression, by upregulating NLRP3 inflammasome activation. (2)
The body controls itself down to its cellular level
via autophagy, the natural process via which the body’s
cells clear out damaged (ie, by inflammation) or unneeded parts. In
a recent study, melatonin increased autophagy
and lessened the degradation of the disc’s
extracellular matrix (technically indicated by a decrease
in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB
signaling pathway). The end conclusion was that melatonin inhibits
intervertebral disc degeneration by stimulating autophagy. (3)
Wow. Rethwill Chiropractic Clinic is inspired by this research to see just
how well melatonin can perform for Eugene back pain related
to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is such a common malady
seen at Rethwill Chiropractic Clinic that positive news of
melatonin’s benefits are quite exciting. A recent
study described that melatonin could modulate
the extracellular matrix of the disc remodeling process started
by IL-1 β. Additionally, melatonin decreased the
inflammatory cell collection and decreased the release of associated
inflammatory markers IL-1β, IL-6, and TNF-α. With this new discovery
that melatonin disrupted the IL-1B feedback loop, researchers
suggested that melatonin may contribute to
the healing process of intervertebral discs after damage was
already present. (1) Rethwill Chiropractic Clinic continues
following the new research on the role inflammation plays
in Eugene disc degeneration and melatonin’s role in reducing
INFLAMMATION AND MELATONIN
The importance of melatonin in assisting
to slow or stop painful conditions due to inflammation is growing.
The description of melatonin as a multitasking molecule affecting
mood, immunity, and energy among other things is quite apropos.
It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically
by blocking the activation of inflammasomes (4) Melatonin’s
formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine.
The pineal gland secretes melatonin naturally. Melatonin influences
the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy
(cell-cleanout) processes. (1) Melatonin’s specific influence on
inflammation and disc degeneration is most attention-getting
to Rethwill Chiropractic Clinic and our Eugene back pain patients.
CONTACT Rethwill Chiropractic Clinic
Listen to this PODCAST
with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different
from any other country on The Back Doctors Podcast with Dr.
Michael Johnson as she illustrates how The Cox® Technic
System of Spinal Pain Management addresses disc
degeneration for relief of chronic low back pain in her patient.
Schedule your Eugene chiropractic appointment with
Rethwill Chiropractic Clinic soon. We can discuss how inflammation affects your
back pain and how melatonin may help with the related disc